Medication Options

A full opioid agonist used to stabilize the brain and reduce cravings.

Methadone has been used safely and effectively for over 50 years to treat opioid dependence. It is a “full opioid agonist,” meaning it fully activates opioid receptors—but in a slow, controlled way that prevents intoxication when taken as prescribed. Methadone keeps the body stable, preventing the painful cycle of withdrawal. This allows patients to focus on rebuilding their lives without cravings or sickness interfering.

How It Works:

• Prevents withdrawal symptoms

• Significantly reduces cravings

• Stabilizes brain chemistry

• Blocks the euphoric effects of other opioids

• Allows patients to function normally (drive, work, care for family)

Recommended For:

• Individuals with a long history of opioid use

• Patients who require a more structured, supervised treatment

• People who have not done well on other medications

A combination medication that reduces cravings and prevents misuse.

Suboxone contains buprenorphine, a partial opioid agonist, and naloxone, which helps prevent misuse by injection. Suboxone is highly effective at stabilizing the body while lowering the risk of dependence and misuse. It can be prescribed in an outpatient setting, making it convenient and accessible.

How it works:

• Buprenorphine activates opioid receptors just enough to prevent withdrawal

• Has a “ceiling effect,” meaning it will not create a strong high

• Naloxone discourages misuse, enhancing safety

• Reduces cravings

• Allows patients to function normally in daily life

Recommended for:

• Patients seeking flexible treatment (take-home doses possible)

• People transitioning off pain pills, heroin, or fentanyl

• Individuals who want a medication with low risk of sedation

A partial opioid agonist used when naloxone is not recommended.

Buprenorphine alone works similarly to Suboxone but does not include naloxone. Buprenorphine stabilizes the body in a safe, controlled manner and is one of the most effective medications for long-term recovery. It can be taken orally daily or as a once a month injection of Sublocade®. Sublocade® is a long-acting form of buprenorphine that delivers a steady dose of medication over 30 days to help reduce cravings, prevent withdrawal symptoms, and support long-term recovery.

How it works:

• Provides steady receptor activation to prevent withdrawal

• Low risk of misuse

• “Ceiling effect” reduces overdose potential

• Long-lasting effects (often once-daily dosing)

Recommended for:

• Pregnant patients

• Individuals with naloxone sensitivity

• Patients transitioning from methadone to buprenorphine.

A non-opioid medication that blocks opioid effects altogether.

Naltrexone is an opioid antagonist, meaning it blocks opioid receptors completely. It contains no opioid ingredients, is not addictive, and does not produce dependence. By removing the rewarding effects of opioids, Naltrexone helps patients maintain sobriety, especially after completing detox or other MAT programs. Naltrexone is available as a monthly extended-release injection (Vivitrol®) or daily tablets.

How it works:

• Blocks the effects of opioids (eliminates ability to get high)

• Helps prevent relapse

• Reduces cravings in many patients

• Contains no opioid activators

Recommended for:

• Individuals who are already fully detoxed

• Patients seeking a completely non-opioid option

• People aiming for relapse prevention after MAT or detox